Interleukin-1b and Interferon-g are Associated with Malaria-Induced Hypoinsulinemic Hypoglycemia in Plasmodium berghei Anka-Infected Mice

Malaria-induced hypoglycemia is recognized as a serious complication of malaria and has one the strongest associations with mortality in children. It been speculated that oxidative stress pro-inflammatory response during parasite infection were involved its pathophysiology. Hence, this study aimed to investigate development malaria-induced Plasmodium berghei ANKA (PbANKA) particular attention involvement c-peptide, interleukin-1b (IL-1b), interferon-g (IFN-g). ICR mice infected 1×107 parasitized erythrocytes PbANKA, parasitemia was monitored, assessed by measuring plasma glucose levels. The change c-peptide level evaluated. IL-1b IFN-g also quantified plasma. found PbANKA resulted indicated significantly (P < 0.05) decrease levels on day 4 post-infection associated parasitemia. slightly increased at 2 post-infection, then decreased since 4. Furthermore, we observed IL-1b, firstly responded, followed increasing PbANKA-induced hypoglycemia. Our findings support idea hypoinsulinemic may be high against infection.